BCR-ABL-IN-9

CAT: 0804-HY-169230Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-169230Size:1 Each

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Description

BCR-ABL-IN-9 (Compound B1) is a BCR-ABL inhibitor that achieves sustained BCR-ABL suppression by forming stable covalent bonds with the ABL kinase. BCR-ABL-IN-9 is also effective in inhibiting the activity of the ABL kinase (IC50 = 1.2 nM) . BCR-ABL-IN-9 possesses anticancer activity[1].

UNSPSC

12352005

Target

Bcr-Abl

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bcr-abl-in-9.html

Smiles

OC1=CC=C(OC)C(C2=CNC3=NC=C(C4=CC(C(N(C)C)=O)=CN=C4)C=C23)=C1

Molecular Formula

C22H20N4O3

Molecular Weight

388.42

References & Citations

[1]Sun J, et al. Rationally designed BCR-ABL kinase inhibitors for improved leukemia treatment via covalent and pro-/dual-drug targeting strategies[J]. Journal of Advanced Research, 2024.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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BCR-ABL-IN-9

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