BCR-ABL-IN-1

CAT: 0804-HY-100314Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-100314Size:1 Each
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Description
BCR-ABL-IN-1 is an inhibitor of BCR-ABL tyrosine kinase, with a pIC50 of 6.46, and may be used in the research of chronic myelogenous leukemia.
CAS Number
[188260-50-6]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Bcr-Abl
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BCR-ABL-IN-1.html
Solubility
10 mM in DMSO
Smiles
NCCCN1C=CC2=C1C=CC=C2C3=NC(NC4=CC=CC(OC(F)(F)C(F)F)=C4)=NC=C3
Molecular Formula
C23H21F4N5O
Molecular Weight
459.44
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Cui J1, et al. BCR-ABL tyrosine kinase inhibitor pharmacophore model derived from a series of phenylaminopyrimidine-based (PAP) derivatives. Bioorg Med Chem Lett. 2013 Apr 15;23 (8) :2442-50.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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