BCR-ABL-IN-2
CAT:
804-HY-18819
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
BCR-ABL-IN-2
- CAS Number: 897369-18-5
- UNSPSC Description: BCR-ABL-IN-2 is an inhibitor of BCR-ABL1 tyrosine kinase, with IC50s of 57 nM, 773 nm for ABL1native and ABL1T315I, respectively.
- Target Antigen: Bcr-Abl
- Type: Reference compound
- Related Pathways: Protein Tyrosine Kinase/RTK
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/BCR-ABL-IN-2.html
- Solubility: 10 mM in DMSO
- Smiles: O=C([C@H]1NCC2=C(C=C(N3N=C(C(C)(C)C)C=C3NC(NC4=CC=CC(Cl)=C4Cl)=O)C=C2)C1)O
- Molecular Weight: 502.39
- References & Citations: [1]Chan WW, et al. Conformational control inhibition of the BCR-ABL1 tyrosine kinase, including the gatekeeper T315I mutant, by the switch-control inhibitor DCC-2036. Cancer Cell. 2011 Apr 12;19(4):556-68.|[2]ARYL SULFONOHYDRAZIDES. US 2008/0113967 A1.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported