BCR-ABL-IN-8

BCR-ABL-IN-8

• CAS Number: 1808288-49-4
• UNSPSC Description: BCR-ABL-IN-8 (compound 26f) is a BCR-ABL inhibitor containing trimethoxy group[1].
• Target Antigen: Bcr-Abl
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/bcr-abl-in-8.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(C1=CC(OC)=C(C(OC)=C1)OC)NC2=CC=C(C)C(NC(C3=CN=C(NC4=CC=C(C)C(N)=C4)N=C3NC)=O)=C2
• Molecular Weight: 571.63
• References & Citations: [1]Liang X, et al. Discovery of 2-((3-Amino-4-methylphenyl)amino)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-ABL-053) as a Potent, Selective, and Orally Available BCR-ABL/SRC/p38 Kinase Inhibitor for Chronic Myeloid Leukemia. J Med Chem. 2016 Mar 10;59(5):1984-2004.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported