BCR-ABL-IN-10

CAT: 0931-T200894-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T200894-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

Bcr-Abl

Related Pathways

Cytoskeletal Signaling, Tyrosine Kinase/Adaptors, Angiogenesis

Bioactivity

BCR-ABL-IN-10 (compound B4) is a covalent BCR-ABL inhibitor featuring an arylvinylsulfonate (AVS) moiety, demonstrating an IC50 of 43.1 nM against ABL kinase. It forms a covalent and stable adduct with ABL kinase, enabling the sustained inhibition of intrinsic BCR-ABL activity. This compound is utilized in the study of chronic myeloid leukemia (CML) .

Smiles

O=C(NC1=CC=C(C=C1)S(=O)(=O)C(F)(F)F)C2=CCN(C3=NC=CC=C3C)CC2

Molecular Formula

C24H22N4O5S

Molecular Weight

478.52

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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GTR19239906-01	BCR-ABL-IN-10
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abx376631-01	BCR/ABL P210 Fusion Protein (BCR/ABL) Antibody
BA8807-1	BCR-ABL-IN-8
XKB36918-01	BCR-ABL-IN-2
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BCR-ABL-IN-10

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