NMS-0963

• Target :

  Syk

• Related Pathways :

  Tyrosine Kinase/Adaptors|||Angiogenesis

• Bioactivity :

  NMS-0963 (compound 1), an orally active inhibitor of spleen tyrosine kinase (SYK), demonstrates an IC50 value of 3 nM. Additionally, NMS-0963 effectively inhibits the proliferation of the BaF3-TEL/SYK cell line at 27 nM [1].

• Smiles :

  C(N[C@H](CN1CCC1)C)(=O)C2=CC(=NN2C)C3=NC(NC4=CC(OC)=CC(OC)=C4)=NC=C3

• Molecular Formula :

  C23H29N7O3

• Molecular Weight :

  451.52

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2765304-82-1