TMX-4116

• Description:

  TMX-4116 is a casein kinase 1α (CK1α) degrader. TMX-4116 shows the degradation preference for CK1α with DC50s less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4116 can be used for the research of multiple myeloma[1].

• UNSPSC:

  12352005

• Target:

  Casein Kinase; Molecular Glues

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; PROTAC; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/tmx-4116.html

• Concentration:

  10mM

• Purity:

  99.76

• Solubility:

  DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C (C (N1N=NC (C2=CSC (C (N3CCCC3) =O) =C2OC) =C1) CC4) NC4=O

• Molecular Formula:

  C17H19N5O4S

• Molecular Weight:

  389.43

• References & Citations:

  [1]Teng M, et al. Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. J Med Chem. 2022 Jan 13;65 (1) :747-756.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CK1

• CAS Number:

  2766385-56-0