TMX-4113

• Description:

  TMX-4113 is a degrader of phosphodiesterase 6D (PDE6D) and casein kinase 1α (CK1α) . TMX-4113 can be used for the research of cancer[1].

• UNSPSC:

  12352005

• Target:

  Casein Kinase; Molecular Glues; Phosphodiesterase (PDE)

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; PROTAC; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/tmx-4113.html

• Purity:

  99.08

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(C(N1N=NC(C2=CSC=C2SC)=C1)CC3)NC3=O

• Molecular Formula:

  C12H12N4O2S2

• Molecular Weight:

  308.38

• References & Citations:

  [1]Teng M, et al. Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. J Med Chem. 2022 Jan 13;65 (1) :747-756.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CK1; PDE6

• CAS Number:

  2766385-92-4