TMX-4102

• Description:

  TMX-4102 is a highly selective phosphatidylinositol 5-phosphate 4-kinase type II gamma (PIP4K2C) binder. TMX-4102 has binding activity to PIP4K2C (KD = 0.45 nM) and has no significant effect on other lipid and non-lipid kinases.TMX-4102 specifically binds to PIP4K2C, regulating its scaffold function rather than its enzymatic activity. TMX-4102 can be used as a tool molecule to study the biological function and potential therapeutic value of PIP4K2C[1].

• UNSPSC:

  12352005

• Target:

  PI5P4K

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Others

• Smiles:

  ClC1=CN=C (NC2=CC3=C (OC[C@] ([H]) (CC4) N3C4=O) N=C2) N=C1C5=CC=CC (C6=CC=CC=C6) =C5

• Molecular Formula:

  C26H20ClN5O2

• Molecular Weight:

  469.92

• References & Citations:

  [1]Teng M, et al. Targeting the Dark Lipid Kinase PIP4K2C with a Potent and Selective Binder and Degrader. Angew Chem Int Ed Engl. 2023 Apr 24;62 (18) :e202302364.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported