TMX-4102

• Description :

  TMX-4102 is a highly selective phosphatidylinositol 5-phosphate 4-kinase type II gamma (PIP4K2C) binder. TMX-4102 has binding activity to PIP4K2C (KD = 0.45 nM) and has no significant effect on other lipid and non-lipid kinases.TMX-4102 specifically binds to PIP4K2C, regulating its scaffold function rather than its enzymatic activity. TMX-4102 can be used as a tool molecule to study the biological function and potential therapeutic value of PIP4K2C[1].

• UNSPSC :

  12352005

• Target :

  PI5P4K

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Others

• Smiles :

  ClC1=CN=C(NC2=CC3=C(OC[C@]([H])(CC4)N3C4=O)N=C2)N=C1C5=CC=CC(C6=CC=CC=C6)=C5

• Molecular Formula :

  C26H20ClN5O2

• Molecular Weight :

  469.92

• References & Citations :

  [1]Teng M, et al. Targeting the Dark Lipid Kinase PIP4K2C with a Potent and Selective Binder and Degrader. Angew Chem Int Ed Engl. 2023 Apr 24;62 (18) :e202302364.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported