TMX-2172

• Description :

  TMX-2172 is a PROTACs degrader for CDK2 and CDK5, with the IC50s of 6.5 and 6.8 nM, respectively. TMX-2172 plays an important role in cancer research (Blue: E3 ligase ligand (HY-W008352) ; Pink: target protein ligand (HY-170748) ; Black: linker (HY-151072) ) [1].

• UNSPSC :

  12352005

• Target :

  CDK; PROTACs

• Related Pathways :

  Cell Cycle/DNA Damage; PROTAC

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Purity :

  99.38

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=C(NC2=NC(NC3=CC=C(S(=O)(NCCOCCOCCOCCOCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)C=C3C)=NC=C2Br)C=CC=C1F)N

• Molecular Formula :

  C41H45BrFN9O11S

• Molecular Weight :

  970.82

• References & Citations :

  [1]Mingxing Teng, et al. Development of CDK2 and CDK5 Dual Degrader TMX-2172. Angew Chem Int Ed Engl. 2020 Aug 10;59 (33) :13865-13870.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CDK2; CDK5

• CAS Number :

  [2488892-09-5]