TMX-4140

• Description :

  TMX-4140 is a selective PIP4K2C inhibitor with a KD of 7.2 nM for PIP4K2C over PIP4K2B. TMX-4140 can be used for synthesis of PROTAC TMX-4153 (HY-153119) [1].

• UNSPSC :

  12352005

• Target :

  Ligands for Target Protein for PROTAC; PIKfyve

• Related Pathways :

  PI3K/Akt/mTOR; PROTAC

• Field of Research :

  Cancer

• Smiles :

  ClC1=CN=C(N=C1C2=CC=CC(C3=CC=CC=C3)=C2)NC4=CC(N5CCCC5=O)=CN=C4

• Molecular Formula :

  C25H20ClN5O

• Molecular Weight :

  441.91

• References & Citations :

  [1]Teng M, et al. Targeting the Dark Lipid Kinase PIP4K2C with a Potent and Selective Binder and Degrader. Angew Chem Int Ed Engl. 2023 Apr 24;62 (18) :e202302364.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2867519-51-3]