TMX-2164

CAT: 0804-HY-148281Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-148281Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TMX-2164 is a potent, irreversible B-cell lymphoma 6 (BCL6) inhibitor with an IC50 value of 152 nM. TMX-2164 displays sustained target engagement and antiproliferative activity in cells[1].
CAS Number
[2418022-85-0]
UNSPSC
12352005
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tmx-2164.html
Solubility
10 mM in DMSO
Smiles
O=C(COC1=CC2=C(N(C)C1=O)C(OC)=CC(NC3=NC(NCC4=CC=CC(S(=O)(F)=O)=C4)=NC=C3Cl)=C2)NC
Molecular Formula
C25H24ClFN6O6S
Molecular Weight
591.01
References & Citations
[1]Teng M, et, al. Rationally Designed Covalent BCL6 Inhibitor That Targets a Tyrosine Residue in the Homodimer Interface. ACS Med Chem Lett. 2020 Apr 3;11 (6) :1269-1273.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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