TMX-2164

• Description:

  TMX-2164 is a potent, irreversible B-cell lymphoma 6 (BCL6) inhibitor with an IC50 value of 152 nM. TMX-2164 displays sustained target engagement and antiproliferative activity in cells[1].

• UNSPSC:

  12352005

• Target:

  Bcl-2 Family

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/tmx-2164.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (COC1=CC2=C (N (C) C1=O) C (OC) =CC (NC3=NC (NCC4=CC=CC (S (=O) (F) =O) =C4) =NC=C3Cl) =C2) NC

• Molecular Formula:

  C25H24ClFN6O6S

• Molecular Weight:

  591.01

• References & Citations:

  [1]Teng M, et, al. Rationally Designed Covalent BCL6 Inhibitor That Targets a Tyrosine Residue in the Homodimer Interface. ACS Med Chem Lett. 2020 Apr 3;11 (6) :1269-1273.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2418022-85-0