TMX-4153

• UNSPSC Description:

  TMX-4153 is a bivalent degrader. TMX-4153 rapidly and selectively degrades endogenous PIP4K2C by recruiting the von Hippel-Lindau (VHL) E3 ligase complex, with a KD value of 42 nM. TMX-4153 can be used to synthesize PROTAC[1].

• Target Antigen:

  Ligands for Target Protein for PROTAC

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/tmx-4153.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  ClC1=CN=C(N=C1C2=CC=CC(C3=CC=CC=C3)=C2)NC4=CC(N(C5=O)CCC5(CC6)CCN6C(CCCCCC(N[C@H](C(N7[C@H](C(N[C@@H](C)C8=CC=C(C9=C(C)N=CS9)C=C8)=O)C[C@@H](O)C7)=O)C(C)(C)C)=O)=O)=CN=C4

• Molecular Weight:

  1079.74

• References & Citations:

  [1]Teng M, et al. Targeting the Dark Lipid Kinase PIP4K2C with a Potent and Selective Binder and Degrader. Angew Chem Int Ed Engl. 2023 Apr 24;62(18):e202302364.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2867519-91-1