TMX-4153

• Description:

  TMX-4153 is a selective PIP4K2C PROTAC degrader. TMX-4153 induces PIP4K2C degradation in MOLT4 cells (DC50 = 24 nM) and HAP1 cells (DC50 = 361 nM) . TMX-4153 can be used for the study of biological functions of PIP4K2C (immune modulation) -related diseases. (Pink: BTK ligand (HY-177432), Blue: VHL Ligand (HY-112078), Black: Linker) [1].

• UNSPSC:

  12352005

• Target:

  PIKfyve; PROTACs

• Type:

  Reference compound

• Related Pathways:

  PI3K/Akt/mTOR; PROTAC

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/tmx-4153.html

• Purity:

  98.96

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  ClC1=CN=C(N=C1C2=CC=CC(C3=CC=CC=C3)=C2)NC4=CC(N(C5=O)CCC5(CC6)CCN6C(CCCCCC(N[C@H](C(N7[C@H](C(N[C@@H](C)C8=CC=C(C9=C(C)N=CS9)C=C8)=O)C[C@@H](O)C7)=O)C(C)(C)C)=O)=O)=CN=C4

• Molecular Formula:

  C59H67ClN10O6S

• Molecular Weight:

  1079.74

• References & Citations:

  [1]Teng M, et al. Targeting the Dark Lipid Kinase PIP4K2C with a Potent and Selective Binder and Degrader. Angew Chem Int Ed Engl. 2023 Apr 24;62 (18) :e202302364.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Von Hippel-Lindau (VHL)

• CAS Number:

  2867519-91-1