TMX-2138

• Description :

  TMX-2138 is a CDKs PROTAC degrader, with IC50s of 8.7 nM, 10.9 nM, 7.0 nM and 25.7 nM for CDK1/cyclinB, CDK2/cyclinA, CDK5/p25 and CDK9/cyclinT1, respectively. TMX-2138 promotes ubiquitination and degradation of CDKs. TMX-2138 can be used for the research of ovarian cancer (Pink: CDKs ligand (HY-151071) ; Blue: E3 ligase CRBN ligand (HY-14658) ; Black: linker (HY-W008352) ) [1].

• UNSPSC :

  12352005

• Target :

  CDK; PROTACs

• Related Pathways :

  Cell Cycle/DNA Damage; PROTAC

• Field of Research :

  Cancer

• Smiles :

  O=C(C1=C(NC2=NC(NC3=CC=C(S(=O)(NCCOCCOCCOCCOCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)C=C3)=NC=C2Br)C=CC=C1F)N

• Molecular Formula :

  C40H43BrFN9O11S

• Molecular Weight :

  956.79

• References & Citations :

  [1]Teng M, et al. Development of CDK2 and CDK5 Dual Degrader TMX-2172. Angew Chem Int Ed Engl. 2020 Aug 10;59 (33) :13865-13870.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CDK1; CDK2; CDK4; CDK5; CDK6; CDK7; CDK9

• CAS Number :

  [2488892-07-3]