BLK degrader 1

• CAS Number:

  3049215-64-4

• UNSPSC Description:

  BLK degrader 1 (compound 9) is a selective degrader of B-lymphoid tyrosine kinase (BLK). BLK degrader 1 shows anticancer activity in several B-lymphoid cell lines[1].

• Target Antigen:

  Others

• Type:

  Reference compound

• Related Pathways:

  Others

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/blk-degrader-1.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CC1=CC=C(C=C1C(NC2=CN=C(N=C2)NC3=CC=CC(N)=C3)=O)NC(C4=CC=C(C=C4)C5=CC(C(F)(F)F)=CC=C5)=O

• Molecular Weight:

  582.58

• References & Citations:

  [1]Fu T, et al. Discovery of 2,5-diaminopyrimidine derivatives as the first series of selective monomeric degraders of B-lymphoid tyrosine kinase. Eur J Med Chem. 2023 Aug 5;256:115460.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported