BLK degrader 1

BLK degrader 1

• CAS Number: 3049215-64-4
• UNSPSC Description: BLK degrader 1 (compound 9) is a selective degrader of B-lymphoid tyrosine kinase (BLK). BLK degrader 1 shows anticancer activity in several B-lymphoid cell lines[1].
• Target Antigen: Others
• Type: Reference compound
• Related Pathways: Others
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/blk-degrader-1.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: CC1=CC=C(C=C1C(NC2=CN=C(N=C2)NC3=CC=CC(N)=C3)=O)NC(C4=CC=C(C=C4)C5=CC(C(F)(F)F)=CC=C5)=O
• Molecular Weight: 582.58
• References & Citations: [1]Fu T, et al. Discovery of 2,5-diaminopyrimidine derivatives as the first series of selective monomeric degraders of B-lymphoid tyrosine kinase. Eur J Med Chem. 2023 Aug 5;256:115460.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported