STING Degrader-1

STING Degrader-1

• UNSPSC Description: STING Degrader-1 (compound 2), a molecular glue, is a potent STING degrader that covalently binds to STING and E3 ligase. STING Degrader-1 exhibits a "hook effect", that degrades 75% STING protein at 10 μM, and degrades ca. 30% STING protein at 30 μM[1].
• Target Antigen: Molecular Glues; STING
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;PROTAC
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/sting-degrader-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NC1=CC=C(N2CCN(C(/C=C/C(C3=CC=C(OC)C=C3)=O)=O)CC2)C=C1)C4=CC=C([N+]([O-])=O)O4
• Molecular Weight: 504.49
• References & Citations: [1]Miki Nakamura, et al. Development of STING degrader with double covalent ligands. Bioorg Med Chem Lett. 2024 Feb 24:102:129677.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported