STING Degrader-1

• UNSPSC Description:

  STING Degrader-1 (compound 2), a molecular glue, is a potent STING degrader that covalently binds to STING and E3 ligase. STING Degrader-1 exhibits a "hook effect", that degrades 75% STING protein at 10 μM, and degrades ca. 30% STING protein at 30 μM[1].

• Target Antigen:

  Molecular Glues; STING

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;PROTAC

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/sting-degrader-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NC1=CC=C(N2CCN(C(/C=C/C(C3=CC=C(OC)C=C3)=O)=O)CC2)C=C1)C4=CC=C([N+]([O-])=O)O4

• Molecular Weight:

  504.49

• References & Citations:

  [1]Miki Nakamura, et al. Development of STING degrader with double covalent ligands. Bioorg Med Chem Lett. 2024 Feb 24:102:129677.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported