Exatecan Intermediate 6

• UNSPSC Description:

  Exatecan Intermediate 6 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 6 can be used to synthesize Antibody-Drug Conjugates (ADCs).

• Target Antigen:

  ADC Cytotoxin; Topoisomerase

• Type:

  Reference compound

• Related Pathways:

  Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/exatecan-intermediate-6.html

• Purity:

  99.95

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  CC(NC(C=C(F)C(C)=C1CCC2)=C1C2=O)=O

• Molecular Weight:

  235.258

• References & Citations:

  [1]Zhang, et al. Intermediate for synthesizing camptothecin derivatives using exatecan mesylate and its preparation method and application. China, CN111470998 A. 2020-07-31.|[2]Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  143655-58-7