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Antitumor agent-156

CAT: 0804-HY-161647Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161647Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Antitumor agent-156 (Compound 20) causes DNA damage and mitochondrial dysfunction, promotes reactive oxygen species generation, activates endoplasmic reticulum stress, and induce apoptosis, autophagy and ferroptosis. Antitumor agent-156 shows superior antitumor activity against cancer cells including Cisplatin resistance cells. Antitumor agent-156 displayS good liver-targeting ability[1].
CAS Number
9007-83-4
UNSPSC
12352005
Target
Apoptosis; Autophagy; Ferroptosis; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-156.html
Smiles
CC(O[C@H]1CC[C@@]2(C)[C@](CC[C@]([C@@](CC[C@]3(C)[C@@]4([H])C[C@@](C)(C(OCCC5=CN(CCOCCOCCOCCOC(CCC(O[Pt]([NH3])([NH3])(Cl)(Cl)Cl)=O)=O)N=N5)=O)CC3)(C)C4=C6)(C)C2C6=O)([H])C1(C)C)=O
Molecular Formula
C48H78Cl3N5O12Pt
Molecular Weight
1218.60
References & Citations
[1]Huang X, et al. Glycyrrhetinic Acid as a Hepatocyte Targeting Ligand-Functionalized Platinum (IV) Complexes for Hepatocellular Carcinoma Therapy and Overcoming Multidrug Resistance. J Med Chem. 2024 May 23;67 (10) :8020-8042.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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