Products for Research Use Only
RegisterLogin

Antitumor agent-171

CAT: 0804-HY-163767-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-163767-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Antitumor agent-171 (Compound 35) is an inhibitor for β-catenin/BCL9 interaction with IC50 of 1.61 μM. Antitumor agent-171 exhibits high affinity to β-catenin with Kd of 0.63 μM. Antitumor agent-171 inhibits the gene expression of axin2 with IC50 of 0.84 μM. Antitumor agent-171 inhibits cell viability of HCT116 with IC50 of 4.39 μM. Antitumor agent-171 activates T cells, promotes antigen presentation, and exhibits antitumor efficacy and good pharmacokinetic characteristics in mouse models[1].
CAS Number
3003004-76-7
UNSPSC
12352005
Target
β-catenin
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-171.html
Purity
98.48
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(C(C)(OC1=CC(N2CCC[C@@H](C2)NC(N(CC3=CC=C(C=C3)C4=CNN=C4)C5CC5)=O)=CC=C1)C)NCC(N6CC[C@@H](C6)O)=O
Molecular Formula
C35H45N7O5
Molecular Weight
643.78
References & Citations
[1]Zhu W, et al., Discovery of Novel 1-Phenylpiperidine Urea-Containing Derivatives Inhibiting β-Catenin/BCL9 Interaction and Exerting Antitumor Efficacy through the Activation of Antigen Presentation of cDC1 Cells. J Med Chem. 2024 Jun 24.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-162128Antitumor agent-130
HY-161425Antitumor agent-149
HY-155034Antitumor agent-102
HY-151292Antitumor agent-74
HY-116447-01Antitumor agent-159
HY-149717Antitumor agent-122
HY-115948Antitumor agent-46
HY-152537Antitumor agent-84
HY-128776Antitumor agent-19
HY-163691Antitumor agent-163

Alternative Products

CatalogName
GTR19236353-01Antitumor agent-171
T10342-01Antitumor agent-2
T211211-01Antitumor agent-203
T209984-01Antitumor agent-156
T209806-01Antitumor agent-151
T209096-01Antitumor agent-131
T206452-01Antitumor agent-200
T205444-01Antitumor agent-198
T200846-01Antitumor agent-188
T89076-01Antitumor agent-175

Popular Products