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HDAC3 degrader-1

CAT: 0804-HY-179682Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179682Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC3 degrader-1 (Compound Z8) is a selective HDAC3 degrader with a DC50 of 2.42 μM. HDAC3 degrader-1 has almost no effect on HDAC1, HDAC2, and HDAC6. HDAC3 degrader-1 inhibits the activation of the NLRP3 inflammasome and reduces the secretion of IL-1β and caspase-1. HDAC3 degrader-1 shows significant efficacy in septic shock and colitis models. HDAC3 degrader-1 can be used in anti-inflammatory research[1].
UNSPSC
12352005
Target
Caspase; HDAC; Interleukin Related; NOD-like Receptor (NLR)
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
FC(CC1)(F)CCN1C([C@@]2(C)CC[C@]3(C)CC[C@@]4(C)[C@]5(C)CCC6C(C)(C)C(C(C#N)=C[C@]6(C)C5=CC=C4[C@]3([H])C2)=O)=O
Molecular Formula
C36H48F2N2O2
Molecular Weight
578.78
References & Citations
[1]Qin H, et al. Synthesis and biological evaluations of novel 18β-glycyrrhetinic acid derivatives as histone deacetylase 3 degraders with anti-inflammatory effects. Eur J Med Chem. 2026 Jan 15;302 (Pt 3) :118391.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 1; HDAC3; IL-1; NLRP3

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