HDAC6 degrader-4

HDAC6 degrader-4

• CAS Number: 2235382-05-3
• UNSPSC Description: HDAC6 degrader-4 is a PROTAC and a selective HDAC6 degrader consists of a non-selective HDAC inhibitor and thalidomide-type E3 ligase ligand. HDAC6 degrader-4 can be used for cancer research[1].
• Target Antigen: HDAC; PROTACs
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/hdac6-degrader-4.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NO)CCCCCCC(N/N=C/C1=CC=C(OCCOCCOCCN2N=NC(CNC3=CC=CC(C(N4C(CC5)C(NC5=O)=O)=O)=C3C4=O)=C2)C=C1)=O
• Molecular Weight: 775.81
• References & Citations: [1]Yang K, et al. Development of the first small molecule histone deacetylase 6 (HDAC6) degraders. Bioorg Med Chem Lett. 2018 Aug 1;28(14):2493-2497.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported