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HDAC6 degrader-4

CAT: 0804-HY-123971-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-123971-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC6 degrader-4 is a PROTAC and a selective HDAC6 degrader consists of a non-selective HDAC inhibitor and thalidomide-type E3 ligase ligand. HDAC6 degrader-4 can be used for cancer research[1].
CAS Number
2235382-05-3
UNSPSC
12352005
Target
HDAC; PROTACs
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac6-degrader-4.html
Solubility
10 mM in DMSO
Smiles
O=C(NO)CCCCCCC(N/N=C/C1=CC=C(OCCOCCOCCN2N=NC(CNC3=CC=CC(C(N4C(CC5)C(NC5=O)=O)=O)=C3C4=O)=C2)C=C1)=O
Molecular Formula
C37H45N9O10
Molecular Weight
775.81
References & Citations
[1]Yang K, et al. Development of the first small molecule histone deacetylase 6 (HDAC6) degraders. Bioorg Med Chem Lett. 2018 Aug 1;28 (14) :2493-2497.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC6

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