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HDAC6 degrader-5

CAT: 0804-HY-170495-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-170495-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC6 degrader-5 (Compound 6) exhibits inhibitory and degradation activity against HDAC6, with an IC50 of 4.95 nM and a DC50 of 0.96 nM. HDAC6 degrader-5 inhibits the release of TNF-α, IL-1β and IL-6, blocks the hepatocyte apoptosis. HDAC6 degrader-5 exhibits anti-inflammatory activity in mouse APAP -induced liver injury models[1].
UNSPSC
12352005
Target
Apoptosis; HDAC; Interleukin Related
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation
Field of Research
Inflammation/Immunology
Concentration
10mM
Purity
99.55
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCC1=CC(C(NC2=CC=CC=C2)=O)=NN1CC3=CC=C(C=C3)C(NO)=O
Molecular Formula
C21H22N4O3
Molecular Weight
378.42
References & Citations
[1]Cui H, et al., Discovery of N-Phenyl-5-propyl-1H-pyrazole-3-carboxamide, with Selective Inhibition and Degradation of HDAC6 for the Treatment of Acute Liver Injury. J Med Chem. 2025 Jan 9;68 (1) :531-554.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC6

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