HDAC6 degrader-1

• UNSPSC Description:

  HDAC6 degrader-1 is a PROTAC that comprises a selective HDAC6 inhibitor Nexturastat A (Nex A) as the HDAC6 binder, a linker and a ligand for recruiting E3 ligase. HDAC6 degrader-1 induces significant degradation of HDAC6, exhibits excellent selectivity against other HDACs, and demonstrates efficient inhibition of cell proliferation[1].

• Target Antigen:

  PROTACs

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/hdac6-degrader-1.html

• Smiles:

  O=C(C1=CC=C(CN(CCCCC2=CN(CCOCCOCCNC3=CC=CC(C(N4C5C(NC(CC5)=O)=O)=O)=C3C4=O)N=N2)C(NC6=CC=CC=C6)=O)C=C1)NO

• Molecular Weight:

  795.84

• References & Citations:

  [1]An Z, et al. Developing potent PROTACs tools for selective degradation of HDAC6 protein [published correction appears in Protein Cell. 2019 Feb 22;:]. Protein Cell. 2019;10(8):606-609.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  2439058-23-6