HDAC1 Degrader-1

• UNSPSC Description:

  HDAC1 Degrader-1 (compound 1a) is an HDAC1 degrader with anticancer activity. HDAC1 Degrader-1 significantly reduces HDAC1 levels in MM.1S multiple myeloma cells[1].

• Target Antigen:

  HDAC

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/hdac1-degrader-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NCCCCCCC(NO)=O)C1=CC=C(NC(CC2(C3)C[C@@H](C4)C[C@H]3C[C@@H]4C2)=O)C=C1

• Molecular Weight:

  455.59

• References & Citations:

  [1]Feller F et al. Targeted Protein Degradation of Histone Deacetylases by Hydrophobically Tagged Inhibitors[J]. ACS Medicinal Chemistry Letters, 2023.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported