PROTAC HDAC6 degrader 1

PROTAC HDAC6 degrader 1

• CAS Number: 2785404-76-2
• UNSPSC Description: PROTAC HDAC6 degrader (Compound A6) is a potent and selective PROTAC HDAC6 degrader with a DC50 of 3.5 nM. PROTAC HDAC6 degrader shows promising antiproliferative activity via inducing apoptosis in myeloid leukemia cell lines[1].
• Target Antigen: Apoptosis; HDAC; PROTACs
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Epigenetics;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-hdac6-degrader-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=CC=C(C=C1)NC(CCCCCCCNC(COC2=CC=CC(C(N3C4CCC(NC4=O)=O)=O)=C2C3=O)=O)=O)NCCCCCCC(NO)=O
• Molecular Weight: 734.80
• References & Citations: [1]Sinatra L, et al. Solid-Phase Synthesis of Cereblon-Recruiting Selective Histone Deacetylase 6 Degraders (HDAC6 PROTACs) with Antileukemic Activity. J Med Chem. 2022 Dec 22;65(24):16860-16878.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported