PROTAC HDAC8 Degrader-1

PROTAC HDAC8 Degrader-1

• UNSPSC Description: Degrader-1 (compound Z16) is a potent and selective HDAC8 PROTAC degrader with an DC50 of 0.27 nM in A549 cells[1].
• Target Antigen: HDAC; PROTACs
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-hdac8-degrader-1.html
• Smiles: O=C(NCC1=CC=C(C(NNCCCCCC)=O)C=C1)CN2CCC(C3=CC=C(NC(CC4)C(NC4=O)=O)C=C3)CC2
• Molecular Weight: 576.73
• References & Citations: [1]Zhao C, et al. Exploration of Hydrazide-Based HDAC8 PROTACs for the Treatment of Hematological Malignancies and Solid Tumors. J Med Chem. 2024 Aug 1.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported