ITK antagonist
CAT:
804-HY-13232
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
ITK antagonist
- CAS Number: 1149753-56-9
- UNSPSC Description: ITK antagonist (compound 10 n) is a potent, orally active and selective ITK (Interleukin-2 inducible T-cell kinase) antagonist (IC50=1 and 20 nM in different assays). ITK antagonist inhibits insulin receptor kinase (IRK) with an IC50 of 160 nM[1].
- Target Antigen: Itk
- Type: Reference compound
- Related Pathways: Protein Tyrosine Kinase/RTK
- Applications: COVID-19-immunoregulation
- Field of Research: Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/itk-antagonist.html
- Solubility: 10 mM in DMSO
- Smiles: CC(C)(O)CN1C2=CC=C(CN[C@@H](C)C(C)(C)C)C=C2N=C1NC(C3=CC=C(C4=CNN=C4)S3)=O
- Molecular Weight: 494.65
- References & Citations: [1]Riether D, et al. 5-Aminomethylbenzimidazoles as potent ITK antagonists. Bioorg Med Chem Lett. 2009;19(6):1588-1591.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported