ITK antagonist

• Description :

  ITK antagonist (compound 10 n) is a potent, orally active and selective ITK (Interleukin-2 inducible T-cell kinase) antagonist (IC50=1 and 20 nM in different assays) . ITK antagonist inhibits insulin receptor kinase (IRK) with an IC50 of 160 nM[1].

• UNSPSC :

  12352005

• Target :

  Itk

• Type :

  Reference compound

• Related Pathways :

  Protein Tyrosine Kinase/RTK

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/itk-antagonist.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(C)(O)CN1C2=CC=C(CN[C@@H](C)C(C)(C)C)C=C2N=C1NC(C3=CC=C(C4=CNN=C4)S3)=O

• Molecular Formula :

  C26H34N6O2S

• Molecular Weight :

  494.65

• References & Citations :

  [1]Riether D, et al. 5-Aminomethylbenzimidazoles as potent ITK antagonists. Bioorg Med Chem Lett. 2009;19 (6) :1588-1591.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1149753-56-9]