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Nrf2 activator-21

CAT: 0804-HY-175548Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175548Size:1 Each
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Description
Nrf2 activator-21 is a Nrf2 activator with dual antioxidant and neuroprotective properties. Nrf2 activator-21 binds to Keap1 Kelch domain and disrupts Keap1-Nrf2 interactions and activate antioxidant defense mechanisms. Nrf2 activator-21 reduces apoptosis and decreases caspase-3 activity in the hippocampal neurons. Nrf2 activator-21 targets cerebral ischemia/reperfusion injury (CIRI) via Nrf2 pathway activation. Nrf2 activator-21 improves neurological function, alleviates anxiety-like behavior, enhances memory in rats with 2-vessel occlusion (2VO) -induced CIRI. Nrf2 activator-21 can be used for the study of cerebral ischemia/reperfusion injury[1].
CAS Number
1912404-14-8
UNSPSC
12352005
Target
Apoptosis; Caspase; Keap1-Nrf2
Related Pathways
Apoptosis; NF-κB
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
COC1=CC=C2C(OC(C(C(/C=C/C3=CC=C(O)C=C3)=O)=C2)=O)=C1
Molecular Formula
C19H14O5
Molecular Weight
322.31
References & Citations
[1]Mohammadnia M, et al. Coumarin-Chalcone derivatives as promising antioxidant agents targeting ischemia/reperfusion injury through Nrf2 pathway activation. Bioorg Chem. 2025 Jul 26;164:108790.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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