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ABCB1/ABCG2-IN-1

CAT: 0804-HY-174435Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174435Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ABCB1/ABCG2-IN-1 (Compound (S, Z) -4b) is an inhibitor of ABCB1 and ABCB2 transporters. ABCB1/ABCG2-IN-1 shows moderate activity in SW620M, -V, and –Mito variants (IC50 ≈ 50 μM) . ABCB1/ABCG2-IN-1 affects methotrexate resistance in vitro. ABCB1/ABCG2-IN-1 can be studied in anticancer research[1].
UNSPSC
12352005
Target
P-glycoprotein
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cancer
Smiles
O=C([C@@]1(CCCN1C/2=O)[H])NC2=C/C3=C(c4cccc4)C=CC=C3.[][Fe][].c5cccc5
Molecular Formula
C24H22FeN2O2
Molecular Weight
426.29
References & Citations
[1]Andrzej Błauż, et al., (2025) . Design, Synthesis, and Biological Evaluation of Ferrocenyl–Cyclo- (Gly-l-Pro) Hybrids Sensitizing Multidrug-Resistant Cancer Cells to Anticancer Agents. ACS Med. Chem. Lett. 2025, 16, 7, 1391–1400
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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