ABCG2-IN-4

• Description:

  ABCG2-IN-4 (Compound K31) is an orally active inhibitor for ABCG2, which reduces the release of Protoporphyrin IX (PPIX) (HY-B1247) from erythrocytes into plasma, and prevents the reduces phototoxicity. ABCG2-IN-4 exhibits anti-inflammatory and antioxidant activity in mouse models[1].

• UNSPSC:

  12352005

• Target:

  BCRP

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Smiles:

  O=C([C@H](CC(NC(C)C)=O)NC1=O)N([C@H]1C2)[C@@H](CC(C)C)C3=C2C4=CC=C(OC)C=C4N3

• Molecular Formula:

  C24H32N4O4

• Molecular Weight:

  440.54

• References & Citations:

  [1]Zhu J, et al., Inhibition of ABCG2 prevents phototoxicity in a mouse model of erythropoietic protoporphyria. Nat Commun. 2024 Dec 4;15 (1) :10557.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2559759-63-4]