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ABCB1-IN-3

CAT: 0804-HY-168921Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168921Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ABCB1-IN-3 (Compound K27) is an orally active inhibitor of ABCB1, and induces apoptosis. ABCB1-IN-3 directly binds to ABCB1 to inhibit efflux function, ensuring stable intracellular concentration of Paclitaxel (PTX) without affecting ABCB1 normal expression. ABCB1-IN-3 significantly increases the sensitivity of ABCB1-mediated multidrug resistance (MDR) to Paclitaxel in vitro, enhances cell cycle arrest, and inhibits proliferation. BCB1-IN-3 combined with Paclitaxel exhibits potent tumor suppression in vivo without generating toxicity[1].
UNSPSC
12352005
Target
Apoptosis; P-glycoprotein
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CN1C2=CC=CC=C2C3=C1C(C4=CC=C(OC)C=C4)=NC=C3
Molecular Formula
C19H16N2O
Molecular Weight
288.34
References & Citations
[1]Wang Y, et al. Design, synthesis, and biological evaluation of β-carboline derivatives as ABCB1 inhibitors for reversing multidrug resistance. Eur J Med Chem. 2025 Feb 13;288:117390.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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