ABCB1-IN-3

• Description:

  ABCB1-IN-3 (Compound K27) is an orally active inhibitor of ABCB1, and induces apoptosis. ABCB1-IN-3 directly binds to ABCB1 to inhibit efflux function, ensuring stable intracellular concentration of Paclitaxel (PTX) (HY-B0015) without affecting ABCB1 normal expression. ABCB1-IN-3 significantly increases the sensitivity of ABCB1-mediated multidrug resistance (MDR) to Paclitaxel in vitro, enhances cell cycle arrest, and inhibits proliferation. BCB1-IN-3 combined with Paclitaxel exhibits potent tumor suppression in vivo without generating toxicity[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; P-glycoprotein

• Related Pathways:

  Apoptosis; Membrane Transporter/Ion Channel

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Smiles:

  CN1C2=CC=CC=C2C3=C1C(C4=CC=C(OC)C=C4)=NC=C3

• Molecular Formula:

  C19H16N2O

• Molecular Weight:

  288.34

• References & Citations:

  [1]Wang Y, et al. Design, synthesis, and biological evaluation of β-carboline derivatives as ABCB1 inhibitors for reversing multidrug resistance. Eur J Med Chem. 2025 Feb 13;288:117390.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported