ABCG2-IN-1

ABCG2-IN-1

• CAS Number: 2559759-40-7
• UNSPSC Description: ABCG2-IN-1 (compound K2), a Ko143 analog, is an orally active ABCG2 inhibitor with an IC50 of 0.13 μM. ABCG2-IN-1 has favorable oral pharmacokinetic profiles in mice[1].
• Target Antigen: BCRP
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/abcg2-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: CC(C)C[C@H]1C2=C(C[C@]3([H])N1C([C@@H](NC3=O)CCC(NC(C)(C)C)=O)=O)C4=CC=C(OC)C=C4N2
• Molecular Weight: 468.59
• References & Citations: [1]Junjie Zhu, et al. Metabolism-guided development of Ko143 analogs as ABCG2 inhibitors. Eur J Med Chem. 2023 Nov 5;259:115666.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported