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ABCB1-IN-2

CAT: 0804-HY-163981Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163981Size:1 Each
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Description
ABCB1-IN-2 (compound 16q) is a functional inhibitor that can directly bind to the ABCB1 protein and stabilize its structure without affecting the expression and subcellular localization of ABCB1. ABCB1-IN-2 can increase the sensitivity of MCF-7/ADR cells to paclitaxel (PTX), increase the accumulation of PTX, and prevent the accumulation and excretion of luciferin Rh123 mediated by ABCB1. ABCB1-IN-2, as an ABCB1-mediated multidrug resistance (MDR) reversal agent, shows a strong ability to reverse MDR[1].
UNSPSC
12352005
Target
P-glycoprotein
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/abcb1-in-2.html
Smiles
COC1=C(OC)C(OC)=CC(C2=C(C3=CC(OC)=C(OC)C(OC)=C3)C(C)=NC4=CC(C5=CC=CS5)=NN24)=C1
Molecular Formula
C29H29N3O6S
Molecular Weight
547.62
References & Citations
[1]Discovery of novel pyrazolo[1,5-a]pyrimidine derivatives as potent reversal agents against ABCB1-mediated multidrug resistance
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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