ABCG2-IN-2

• Description:

  ABCG2-IN-2 is a potent ABCG2 inhibitor with favorable oral pharmacokinetic profiles in mice. ABCG2-IN-2 can be used for the research of tumor multidrug resistance (MDR) and erythropoietic protoporphyria (EPP) [1].

• UNSPSC:

  12352005

• Target:

  BCRP

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/abcg2-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(C)C[C@H]1C2=C(C[C@]3([H])N1C([C@@H](NC3=O)CCC(NC(C)C)=O)=O)C4=CC=C(OC)C=C4N2

• Molecular Formula:

  C25H34N4O4

• Molecular Weight:

  454.56

• References & Citations:

  [1]Zhu J, et al. Metabolism-guided development of Ko143 analogs as ABCG2 inhibitors. Eur J Med Chem. 2023 Nov 5;259:115666. doi: 10.1016/j.ejmech.2023.115666. Epub 2023 Jul 20.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2559759-59-8