ABCG2-IN-5

• Description:

  ABCG2-IN-5 (Compound 10) is a is a selective ABCG2 inhibitor, with an IC50 of 0.34 µM. ABCG2-IN-5 can be used for the study of ABCG2-overexpressing tumors such as non-small cell lung cancer (NSCLC) [1].

• UNSPSC:

  12352005

• Target:

  BCRP

• Related Pathways:

  Membrane Transporter/Ion Channel

• Field of Research:

  Cancer

• Smiles:

  COC1=CC(OC)=C(C(O)=C1)C(/C=C/C2=CC(OC)=C(C(OC)=C2)OC)=O

• Molecular Formula:

  C20H22O7

• Molecular Weight:

  374.38

• References & Citations:

  [1]Ruginsk BE, et al. New players from the old chalcone scaffold: Synthesis, identification, and characterization of new potent ABCG2 inhibitors. Eur J Med Chem. 2025 Dec 5;299:118077.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [190323-50-3]