ABCG2-IN-3

CAT: 0804-HY-119724-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-119724-01Size:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
ABCG2-IN-3 (Compound 52) is a selective inhibitor for breast cancer resistance protein (ABCG2), with an IC50 of 0.238 µM. ABCG2-IN-3 reverses the ABCG2-mediated resistance toward SN-38 and inhibit the ATPase activity[1].
CAS Number
[1942919-63-2]
UNSPSC
12352005
Target
BCRP
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/abcg2-in-3.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C=C1)C(N2C(C3=C(CC2)C(C=CC=C4)=C4N3)C5=CC(Cl)=C(C=C5)Cl)=O
Molecular Formula
C25H20Cl2N2O2
Molecular Weight
451.34
References & Citations
[1]Spindler A, et al., Synthesis and Investigation of Tetrahydro-β-carboline Derivatives as Inhibitors of the Breast Cancer Resistance Protein (ABCG2) . J Med Chem. 2016 Jul 14;59 (13) :6121-35.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-178386ABCG2-IN-5
HY-170396ABCG2-IN-4
HY-155653ABCG2-IN-2
HY-155652ABCG2-IN-1
HY-P703266-01ABCG2, Human (HEK293)
HY-174435ABCB1/ABCG2-IN-1
HY-P84881-01ABCG2 Antibody (YA4578, Mouse)
HY-P80002-01ABCG2 Antibody (YA648, Rabbit)
HY-P703267-01ABCG2, Human (E211Q, HEK293)
HY-P87841ABCG2 Antibody (YA7526, Rabbit)

Alternative Products

CatalogName
MBS8534348-01ABCG2
554079-01ABCG2 (Biotin)
532631ABCG2 discontinued
A11250-100UGABCG2 Antibody
sc-18841ABCG2 (5D3)
sc-69989ABCG2 (6D170)

Popular Products