Keap1-IN-2

• Description :

  Keap1-IN-2 (Compound 164) is a KEAP1 inhibitor (IC50: 2 nM) . Keap1-IN-2 indirectly activates Nrf2 by inhibiting KEAP1, thereby enhancing the antioxidant capacity of cells. Keap1-IN-2 promotes the accumulation and nuclear translocation of Nrf2 by blocking KEAP1-mediated Nrf2 degradation. Keap1-IN-2 can be used to study diseases associated with oxidative stress, such as inflammatory bowel disease, Crohn's disease, and immune diseases such as ulcerative colitis[1].

• UNSPSC :

  12352005

• Target :

  Keap1-Nrf2

• Related Pathways :

  NF-κB

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Smiles :

  CC(N1[C@H](C2=CC(Cl)=NC(C3=NC=NC(C(NC)=O)=C3)=C2)CN(C[C@H]1C)C(C=C)=O)=O

• Molecular Formula :

  C21H23ClN6O3

• Molecular Weight :

  442.90

• References & Citations :

  [1]Karl BEDKE, et al. Keap1 inhibitors and uses thereof. WO2024259171A2. WO. 2024-06-13

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3066895-41-5]