Products for Research Use Only
RegisterLogin

Keap1-IN-2

CAT: 0804-HY-174287Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-174287Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Keap1-IN-2 (Compound 164) is a KEAP1 inhibitor (IC50: 2 nM) . Keap1-IN-2 indirectly activates Nrf2 by inhibiting KEAP1, thereby enhancing the antioxidant capacity of cells. Keap1-IN-2 promotes the accumulation and nuclear translocation of Nrf2 by blocking KEAP1-mediated Nrf2 degradation. Keap1-IN-2 can be used to study diseases associated with oxidative stress, such as inflammatory bowel disease, Crohn's disease, and immune diseases such as ulcerative colitis[1].
CAS Number
3066895-41-5
UNSPSC
12352005
Target
Keap1-Nrf2
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
CC(N1[C@H](C2=CC(Cl)=NC(C3=NC=NC(C(NC)=O)=C3)=C2)CN(C[C@H]1C)C(C=C)=O)=O
Molecular Formula
C21H23ClN6O3
Molecular Weight
442.90
References & Citations
[1]Karl BEDKE, et al. Keap1 inhibitors and uses thereof. WO2024259171A2. WO. 2024-06-13
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-170301Keap1-IN-1
HY-147548Keap1-Nrf2-IN-10
HY-146578Keap1-Nrf2-IN-8
HY-143893Keap1-Nrf2-IN-6
HY-143892Keap1-Nrf2-IN-5
HY-157929Keap1-Nrf2-IN-19
HY-147924Keap1-Nrf2-IN-11
HY-144099Keap1-Nrf2-IN-4
HY-157928Keap1-Nrf2-IN-18
HY-150579-01Keap1-Nrf2-IN-13

Alternative Products

CatalogName
GTR19263464-01Keap1-IN-2
sc-365626Keap1 (G-2)
538249-01Keap1
sc-365626 HRPKeap1 (G-2) HRP
sc-365626 PEKeap1 (G-2) PE
sc-365626 ACKeap1 (G-2) AC
sc-365626 FITCKeap1 (G-2) FITC
GTR19274249-01Keap1/Nrf2/ARE activator 2
YP-W13339-01Human KEAP1 (KEAP1) ELISA Kit
TMAB-01018-01Anti-KEAP1 Polyclonal Antibody 2

Popular Products