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Keap1/Nrf2/ARE activator 2

CAT: 0013-GTR19274249-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274249-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Keap1/Nrf2/ARE activator 2 is an activator of the Keap1/Nrf2/ARE pathway, acting as a non-competitive inhibitor of AChE with an IC50 of 14.79 μM and a Ki of 1.35 μM. It enhances Nrf2 nuclear translocation, thereby upregulating antioxidant gene expression and boosting cellular defenses against oxidative stress. In PC12 cells, Keap1/Nrf2/ARE activator 2 demonstrates significant neuroprotective effects against damage induced by H2O2 and Scopolamine (SCA) . In zebrafish models, it alleviates cognitive deficits and neuroinflammation associated with SCA-induced impairments. This compound is relevant for Alzheimer's disease research.
CAS Number
3105470-83-2
Smiles
O=C1C (=COC2=C (O) C (O) =CC=C12) C=3C=CC (Br) =CC3
Molecular Formula
C15H9BrO4
Molecular Weight
333.14
Storage Conditions
-20°C
Notes
For research use only.

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