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EGFR-IN-161

CAT: 0804-HY-172780Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-172780Size:1 Each
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Description
EGFR-IN-161 (Compound DD-8) is a potent and reversible inhibitor of L858R/T790M/C797S mutant EGFR kinases, with an IC50 of 0.87 nM. EGFR-IN-161 can induce apoptosis process, G1-phase arrestation, and migration inhibition in tumor cells[1].
CAS Number
3031099-34-7
UNSPSC
12352101
Target
Apoptosis; EGFR
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
COC1=CC(N(CCN(C)C)C)=C(C=C1NC2=NC(C3=CN(C4=C3C=CC=C4)CCCO)=CC=N2)/N=C/C5=C(C(Cl)=NC=C5)Cl
Molecular Formula
C33H36Cl2N8O2
Molecular Weight
647.60
References & Citations
[1]Ding S, et, al. Design, synthesis and biological evaluation of imine-containing inhibitors against the triple-mutant EGFR kinases based on the scaffold of osimertinib. Bioorg Chem. 2025 Jun 15:160:108474.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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