WT-161 (Standard)

• Description :

  WT-161 (Standard) is the analytical standard of WT-161 (HY-100871) . This product is intended for research and analytical applications. WT-161 is a potent and selective HDAC6 inhibitor with an IC50 of 0.40 nM[1]. WT-161 also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2) [2].

• Target :

  Apoptosis; Beta-lactamase; HDAC; Reference Standards

• Related Pathways :

  Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Others

• Field of Research :

  Cancer

• Smiles :

  O=C(N/N=C/C1=CC=C(N(C2=CC=CC=C2)C3=CC=CC=C3)C=C1)CCCCCCC(NO)=O

• Molecular Formula :

  C27H30N4O3

• Molecular Weight :

  458.55

• References & Citations :

  [1]Hideshima T, et al. Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma. Proc Natl Acad Sci U S A. 2016 Nov 15;113 (46) :13162-13167.|[2]Severin Lechner, et al. Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target. Nat Chem Biol. 2022 Apr 28.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards

• CAS Number :

  [1206731-57-8]