KIM-161

• Description :

  KIM-161 is a PIK3CA inhibitor. KIM-161 has significant antiproliferative activity with IC50 values of 1.428 and 1.562 µM against PI3KCA mutant breast cancer MCF7 and T47D cells, respectively. KIM-161 induces apoptosis and cell cycle arrest by inhibiting the PI3K/AKT/mTOR signaling pathway and inducing ROS production. KIM-161 can be used to study breast cancer and its PI3KCA mutant subtypes[1].

• UNSPSC :

  12352211

• Target :

  Akt; Apoptosis; mTOR; PI3K; Reactive Oxygen Species (ROS)

• Related Pathways :

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR

• Field of Research :

  Cancer

• Smiles :

  O=C(NCC1=CC=CC=C1)CC2=CC=C(N3C(/C(N=C3C)=C/C4=CC=C(OC)C=C4)=O)C=C2

• Molecular Formula :

  C27H25N3O3

• Molecular Weight :

  439.51

• References & Citations :

  [1]AlKharboush DF, et al. Exploring a kinase inhibitor targeting PI3KCA mutant cancer cells. J Biomol Struct Dyn. 2025 May 19:1-18.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2559686-28-9]