V-161

CAT: 0804-HY-W436428Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-W436428Size:1 Each
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Description
V-161 is the orally active inhibitor for Na+-V-ATPase with an IC50 of 144 nM. V-161 inhibits Enterococcus hirae and Vancomycin-resistant Enterococcus faecium (VRE) under alkaline condition with MIC of 4 µg/mL and 4 µg/mL. V-161 inhibits colonization of VRE in mouse small intestine[1].
CAS Number
[69570-95-2]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Bacterial; Na+/K+ ATPase
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Infection
Smiles
CC1=CC2=C(C=C1)N=C(N2)C3=CC=C(C=C3)N(C)C
Molecular Formula
C16H17N3
Molecular Weight
251.33
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Suzuki K, et al., Na+-V-ATPase inhibitor curbs VRE growth and unveils Na+ pathway structure. Nat Struct Mol Biol. 2024 Nov 21.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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