V-161

• Description :

  V-161 is the orally active inhibitor for Na+-V-ATPase with an IC50 of 144 nM. V-161 inhibits Enterococcus hirae and Vancomycin-resistant Enterococcus faecium (VRE) under alkaline condition with MIC of 4 µg/mL and 4 µg/mL. V-161 inhibits colonization of VRE in mouse small intestine[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  Bacterial; Na+/K+ ATPase

• Related Pathways :

  Anti-infection; Membrane Transporter/Ion Channel

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Smiles :

  CC1=CC2=C(C=C1)N=C(N2)C3=CC=C(C=C3)N(C)C

• Molecular Formula :

  C16H17N3

• Molecular Weight :

  251.33

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Suzuki K, et al., Na+-V-ATPase inhibitor curbs VRE growth and unveils Na+ pathway structure. Nat Struct Mol Biol. 2024 Nov 21.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [69570-95-2]