WT-161

CAT: 0804-HY-100871-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-100871-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
WT-161 is a potent and selective HDAC6 inhibitor with an IC50 of 0.40 nM[1]. WT-161 also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2) [2].
CAS Number
[1206731-57-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Beta-lactamase; HDAC
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/WT-161.html
Concentration
10mM
Purity
98.04
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(N/N=C/C1=CC=C(N(C2=CC=CC=C2)C3=CC=CC=C3)C=C1)CCCCCCC(NO)=O
Molecular Formula
C27H30N4O3
Molecular Weight
458.55
Precautions
H302, H315, H319, H335
References & Citations
[1]Hideshima T, et al. Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma. Proc Natl Acad Sci U S A. 2016 Nov 15;113 (46) :13162-13167.|[2]Severin Lechner, et al. Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target. Nat Chem Biol. 2022 Apr 28.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC2; HDAC3; HDAC6; HDAC8

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