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PRMT5-MTA-IN-3

CAT: 0804-HY-172733Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-172733Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PRMT5-MTA-IN-3 (Compound P2A) is an orally active and selective protein arginine methyltransferase 5 (PRMT5) inhibitor. PRMT5-MTA-IN-3 inhibits cell proliferation in the MTAP-deficient colorectal cancer HCT - 116 cell line with an IC50 value of 5 nM. PRMT5-MTA-IN-3 is promising for research of cancers, especially for MTAP-deficient tumors, such as colorectal cancer, non-small cell lung cancer, pancreatic cancer[1].
CAS Number
3028674-29-2
UNSPSC
12352211
Target
Histone Methyltransferase
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CN1N=CC2=C1C(N)=NC=C2NC(C(N([C@@H]3COC4=CC(C(F)(F)F)=CC=C43)C)=O)=O
Molecular Formula
C19H17F3N6O3
Molecular Weight
434.37
References & Citations
[1]Liu B, et al. Prmt5-mta inhibitor. WO2024152973A1. 2024-07-25.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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