PRMT5-MTA-IN-4

• Target:

  Histone Methyltransferase

• Related Pathways:

  Chromatin/Epigenetic

• Bioactivity:

  PRMT5-MTA-IN-4 (Compound 30) is a potent irreversible inhibitor of protein arginine methyltransferase 5 (PRMT5) with an IC50 of 8 nM. It obstructs arginine methylation, hinders ribosomal RNA processing, and suppresses cell cycle-related protein expression. This compound shows antiproliferative activity in various tumor cell lines, exemplified by an IC50 of 0.3 ?M in DLD-1 cells. PRMT5-MTA-IN-4 holds potential for research into hematological malignancies such as acute myeloid leukemia and diffuse large B-cell lymphoma.

• Smiles:

  N#CC1=C (OC2 (C) CC2) C=C (Cl) C (F) =C1C3=C (C=NN3C) C=4C=C (C=C) C=5C (=O) NN=C (C5C4) CN

• Molecular Formula:

  C26H22ClFN6O2

• Molecular Weight:

  504.94

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3025838-18-7