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PRMT5-MTA-IN-5

CAT: 0013-GTR19263710-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263710-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PRMT5-MTA-IN-5 (Compound 7) is an orally active, irreversible inhibitor of the PRMT5-MTA complex (PRMT5•MTA) with an IC50 value of 1.15 nM. It effectively blocks arginine methylation, impedes the processing of ribosomal RNA, and suppresses the expression of proteins related to the cell cycle. PRMT5-MTA-IN-5 significantly inhibits the proliferation of tumor cells lacking MTAP and shows potential for research into MTAP-deficient solid tumors, such as liver, breast, and pancreatic cancers.
CAS Number
3078322-88-7
Field of Research
Epigenetics & Chromatin
Smiles
N#CC=1C (=C (F) C (=CC1N2CC (=C) C2) C) C3=C (C=NN3C) C=4C=C (C=C) C=5C (=O) NN=C (C5C4) CN
Molecular Formula
C27H24FN7O
Molecular Weight
481.52
Storage Conditions
-20°C
Notes
For research use only.

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