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PRMT5-MTA-IN-6

CAT: 0804-HY-174983Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174983Size:1 Each
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Description
PRMT5-MTA-IN-6 (Compound 31) is a selective MTA-cooperative PRMT5 inhibitor. PRMT5-MTA-IN-6 exhibits potent inhibitory activity against PRMT5MTA (IC50: 6.6 nM) . PRMT5-MTA-IN-6 selectively inhibits the growth of MTAP-deleted HCT-116 cells (IC50: 319 nM) . PRMT5-MTA-IN-6 can be used in the research of MTAP-deleted tumors[1].
UNSPSC
12352005
Target
Histone Methyltransferase
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
NCC1=NNC(C2=CC=C(C=C21)C3=C4N(CCN4N=C3)CC5=CC(C6CC6)=CC7=C5OCC7)=O
Molecular Formula
C26H26N6O2
Molecular Weight
454.52
References & Citations
[1]Yang Y, et al. Discovery of Novel MTA-Cooperative PRMT5 Inhibitors with a 2,3-Dihydro‑1H‑imidazo[1,2‑b]pyrazole Scaffold. ACS Med Chem Lett. 2025 Jun 27;16 (7) :1313-1322.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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