PRMT5-MTA-IN-1

• UNSPSC Description:

  PRMT5-MTA-IN-1 (Compound A9a) is an inhibitor for protein arginine methyltransferase PRMT5-MTA. PRMT5-MTA-IN-1 inhibits the proliferation of colorectal cancer cell HCT116 wildtype and MTAP del mutant, with an IC50 of 16 nM and 2.47 μM. PRMT5-MTA-IN-1 exhibits good liver microsomal stability and film permeability. PRMT5-MTA-IN-1 exhibits good pharmacokinetic characteristics in CD-1 mice[1].

• Target Antigen:

  Histone Methyltransferase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/prmt5-mta-in-1.html

• Smiles:

  CC1=C(C(N)=NC2=CC(F)=C(C=C21)C(N([C@@H]3COC4=CC(C(F)(F)F)=CC=C43)C)=O)CO

• Molecular Weight:

  449.40

• References & Citations:

  [1]Liu B et al., PRMT5-MTA inhibitors. CN118271307A.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported