PRMT5-IN-50

• Description :

  PRMT5-IN-50 is an orally active and selective inhibitor of PRMT5. PRMT5-IN-50 has good metabolic stability and low clearance rate in human liver microsomes. PRMT5-IN-50 inhibits SDMA/HCT116-MTAPdel and SDMA/HCT116-MTAPwt with IC50s value of 1.0, 536 nM for arginine symmetric methylation, 19, 1620 nM for anti-proliferation, respectively. PRMT5-IN-50 inhibits tumor growth in mice[1].

• UNSPSC :

  12352005

• Target :

  Histone Methyltransferase

• Related Pathways :

  Epigenetics

• Field of Research :

  Cancer

• Smiles :

  C[C@@H](N(C(C1=CC=C2N=C(C(C3CC3)=CC2=C1)N)=O)CC4=CC=C(C=N4)C(F)(F)F)C5=NC=CC=N5

• Molecular Formula :

  C26H23F3N6O

• Molecular Weight :

  492.50

• References & Citations :

  [1]Liu B, et al. Prmt5-mta inhibitor. WO2023207556A1.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3002409-47-1]